Nigel H Greig Selected Research

pifithrin

1/2020	The p53 inactivators pifithrin-μ and pifithrin-α mitigate TBI-induced neuronal damage through regulation of oxidative stress, neuroinflammation, autophagy and mitophagy.
1/2018	Neuroprotective effects of pifithrin-α against traumatic brain injury in the striatum through suppression of neuroinflammation, oxidative stress, autophagy, and apoptosis.
1/2018	Sequential combined Treatment of Pifithrin-α and Posiphen Enhances Neurogenesis and Functional Recovery After Stroke.
12/2016	Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury.
5/2009	Delayed treatment with a p53 inhibitor enhances recovery in stroke brain.
6/2004	The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha.
11/2002	p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Nigel H Greig Research Topics

Disease

108	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 01/2002
34	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2021 - 03/2002
30	Parkinson Disease (Parkinson's Disease) 01/2022 - 11/2002
26	Neuroinflammatory Diseases 04/2022 - 09/2007
22	Type 2 Diabetes Mellitus (MODY) 01/2020 - 03/2002
21	Inflammation (Inflammations) 04/2022 - 09/2007
21	Traumatic Brain Injuries (Traumatic Brain Injury) 03/2022 - 09/2011
20	Stroke (Strokes) 04/2022 - 11/2002
18	Cognitive Dysfunction 11/2022 - 11/2002
13	Neuroblastoma 12/2021 - 11/2002
13	Nervous System Diseases (Neurological Disorders) 01/2021 - 07/2012
12	Amyloid Plaque 01/2021 - 01/2002
12	Dementia (Dementias) 12/2018 - 01/2002
11	Disease Progression 01/2022 - 07/2005
11	Brain Concussion (Cerebral Concussion) 01/2020 - 10/2013
10	Neoplasms (Cancer) 04/2022 - 11/2003
5	Infarction (Infarctions) 02/2020 - 03/2007
5	Ischemic Stroke 01/2020 - 03/2010
5	Multiple Myeloma 01/2020 - 11/2003
5	Insulin Resistance 01/2019 - 06/2012
5	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2016 - 12/2004
4	Gliosis 07/2021 - 03/2015
4	Brain Injuries (Brain Injury) 02/2020 - 01/2007
4	Brain Ischemia (Cerebral Ischemia) 01/2019 - 06/2004
3	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 04/2022 - 05/2009
3	Obesity 01/2020 - 06/2012
3	Hypoxia (Hypoxemia) 01/2018 - 12/2004
3	Huntington Disease (Huntington's Disease) 01/2015 - 02/2009
3	Memory Disorders (Memory Loss) 01/2013 - 07/2012
2	Schizophrenia (Dementia Praecox) 01/2021 - 01/2015
2	Mental Disorders (Mental Disorder) 01/2021 - 08/2015
2	Dyskinesias (Dyskinesia) 01/2020 - 12/2019
2	Craniocerebral Trauma (Head Injury) 01/2020 - 09/2007
2	Contusions 09/2019 - 01/2019
2	Cerebrovascular Disorders (Cerebrovascular Occlusion) 04/2019 - 07/2012

Drug/Important Bio-Agent (IBA)

41	Pharmaceutical PreparationsIBA 04/2022 - 02/2003
39	Proteins (Proteins, Gene)FDA Link 04/2021 - 03/2002
28	Amyloid (Amyloid Fibrils)IBA 11/2022 - 12/2004
25	Glucagon-Like Peptide 1 (GLP 1)IBA 12/2021 - 03/2002
24	Peptides (Polypeptides)IBA 02/2022 - 01/2002
20	Exenatide (Byetta)FDA Link 01/2020 - 03/2002
20	Amyloid beta-PeptidesIBA 01/2017 - 01/2002
18	phenserineIBA 02/2020 - 12/2004
16	CytokinesIBA 01/2022 - 01/2004
15	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2020 - 11/2002
15	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2019 - 11/2003
14	Thalidomide (Thalomid)FDA Link 04/2021 - 11/2003
14	Glucagon-Like Peptide-1 ReceptorIBA 01/2017 - 03/2002
13	Cholinergic Agents (Cholinergics)IBA 02/2022 - 05/2004
12	Neuroprotective AgentsIBA 01/2022 - 11/2002
12	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 03/2002
12	ButyrylcholinesteraseIBA 01/2017 - 01/2002
11	AcetylcholinesteraseIBA 02/2020 - 05/2004
10	pomalidomideIBA 04/2022 - 07/2013
9	Biomarkers (Surrogate Marker)IBA 01/2021 - 12/2008
9	3,6'-dithiothalidomideIBA 12/2019 - 09/2011
9	Blood Glucose (Blood Sugar)IBA 01/2017 - 09/2002
7	pifithrinIBA 01/2020 - 11/2002
6	Glutamic Acid (Glutamate)FDA Link 12/2021 - 12/2004
6	IncretinsIBA 06/2020 - 06/2010
6	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 03/2020 - 01/2006
6	Rivastigmine (Exelon)FDA LinkGeneric 03/2020 - 01/2002
6	MicroRNAs (MicroRNA)IBA 01/2019 - 01/2015
5	SynucleinsIBA 04/2022 - 03/2011
5	Immunomodulating AgentsIBA 07/2021 - 01/2019
5	Messenger RNA (mRNA)IBA 01/2020 - 11/2002
5	tartaric acid (tartrate)FDA Link 01/2020 - 07/2005
5	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2014 - 07/2005
4	Caspase 3 (Caspase-3)IBA 03/2022 - 03/2005
4	Biological ProductsIBA 01/2022 - 07/2003
4	Oxidopamine (6 Hydroxydopamine)IBA 01/2020 - 07/2018
4	Glucagon-Like Peptide-1 Receptor AgonistsIBA 04/2019 - 12/2004
4	AntioxidantsIBA 10/2018 - 01/2007
4	Insulin (Novolin)FDA Link 01/2018 - 03/2002
4	LipopolysaccharidesIBA 01/2018 - 01/2011
4	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 03/2014 - 06/2012
4	EnzymesIBA 01/2014 - 08/2006
4	Cholinesterases (Cholinesterase)IBA 08/2013 - 07/2005
4	CarbamatesIBA 06/2012 - 02/2005
3	alpha-SynucleinIBA 01/2022 - 03/2009
3	Lenalidomide (CC 5013)FDA Link 01/2019 - 07/2013
3	Transcription Factors (Transcription Factor)IBA 01/2018 - 06/2004
3	Hormones (Hormone)IBA 01/2018 - 03/2002
3	Therapeutic UsesIBA 01/2018 - 01/2016
3	Oxygen (Dioxygen)IBA 12/2017 - 01/2014
3	Hypoglycemic Agents (Hypoglycemics)IBA 05/2017 - 02/2009
3	Amyloidogenic ProteinsIBA 01/2015 - 02/2005
3	Neurotransmitter Agents (Neurotransmitter)IBA 01/2014 - 11/2005
3	PhysostigmineIBA 07/2010 - 02/2005
3	IronIBA 03/2009 - 11/2002
3	Amyloid beta-Protein Precursor (Amyloid Protein Precursor)IBA 01/2007 - 10/2002
2	ChemokinesIBA 01/2022 - 01/2020
2	KATP ChannelsIBA 01/2021 - 01/2010
2	Complement System Proteins (Complement)IBA 01/2021 - 01/2020
2	Presenilin-1IBA 01/2021 - 07/2009
2	Levodopa (L Dopa)FDA LinkGeneric 01/2020 - 12/2019
2	Glucagon (Glukagon)FDA Link 01/2020 - 04/2019
2	BenserazideIBA 01/2020 - 12/2019
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 10/2018

Therapy/Procedure

15	Therapeutics 04/2022 - 01/2002